Human
Antigens

As a company we began with the production of high quality human antigens. Over the years the number of natural and recombinant antigens has grown to meet the needs of our customers.

Recombinant Antigens

Epstein Barr Virus, EBNA-1

EBNA-1: 27 kd antigen of EBNA-1. This antigen is constructed of the C-terminal one-third of the native protein. It is traditionally used as a marker for chronic infections but may be useful in IgA and IgM studies. It is usable in EIA application, direct conjugation in capture assays or in western blot analysis. Lot sizes to 100 mg.

RF0403 in PBS, 140 mM NaCl $1,750/mg

Epstein Barr Virus, Early Antigen (D)

Early Antigen (D): 28kd antigen of EA-D. It is used as a marker of chronic or acute infection, in EIA applications, capture assays or in western blot analysis.

RF0405 tris buffer solution, fused to MBP $1,750/mg
RF0419 in PBS, 500 mM NaCl $1,750/mg

Epstein Barr Virus, VCA P-18 & P-18/GP125 Fusion

VCA P-18 & P-18/GP125 Fusion: An important part of the VCA complex. It is a useful marker in acute and convalescent serologies. It can be used in EIA, capture assays, direct conjugation, or in western blot analysis.

RF0407* EBV VCA P-18 in PBS, 500 mM NaCl , truncated $1,750/mg
RF0415 VCA P-18/truncated GP125 fusion protein, in PBS, 500 mM NaCl, 3M Urea $1,750/mg
RF0431 VCA P-18 full length in PBS, 500 mM NaCl $1,750/mg
RF0445 P-18/EBNA-1 fusion protein in PBS, 500 mM NaCl $1,750/mg
*Constructed as a fusion protein to truncated MBP.

Herpes Simplex Type-Specific Antigen

HSV 1 and 2 are the cause of vesicular lesions of oral and genital mucosa and may involve other sites. The use of type-specific antigens can be used to serotype individuals.

Herpes Simplex Virus Type 1
RF0182 Type-specific antigen gG1, in PBS, 500 mM NaCl $600/mg
Herpes Simplex Virus Type 2
RF0236 Type-specific antigen gG2 (aa 343-649), in PBS, 500 mM NaCl $600/mg
RF0237 Type-specific antigen gG2 (aa 525-578), in PBS, 500 mM NaCl $600/mg

Rubella Virus

Rubella is known for causing congenital birth defects if contracted during pregnancy. These defects include cataracts and heart abnormalities. The E2 protein is a common structural protein and is a major membrane glycoprotein in the Rubella virus.

RF0823 E2 protein, in PBS, 500 mM NaCl, 3M Urea $600/mg

West Nile Virus

West Nile Virus is a flavivirus which is spread from mosquitos to humans. Typical symptoms include mild fever, head and body aches and generalized myalgia, with serious infections causing encephalitis and neuronal degeneration.

RF2421 E protein domain III, in PBS, 500 mM NaCl $800/mg

Dengue Virus

Dengue is a flavivirus and has four known serotypes. Acquired immunity to one type provides partial immunity to the others. Symptoms include severe fever, hemorrhage, conjunctival congestion, nausea and vomiting. This antigen represents domain 3 of the envelope glycoprotein.

RF5162 serotype 1 truncated E protein, in PBS, 500 mM NaCl $600/mg
RF3254 serotype 2 truncated E protein, in 50 mM glycine buffer, pH 9,140 mM NaCl $600/mg
RF5063 serotype 3 truncated E protein, in PBS, 500 mM NaCl $600/mg
RF5264 serotype 4 truncated E protein, in PBS, 500 mM NaCl $600/mg

Toxoplasma gondii P30

Toxoplasma gondii is an important pathogen in the immunocompromised population and in pregnant women. P30 is a membrane-bound antigen with a long history of utility in serodiagnostics.

RF1030* in PBS, 500 mM NaCl $600/mg
RF1056 in PBS, 500 mM NaCl $600/mg
*Produced in yeast.

Treponema pallidum

Syphilis is an old but increasingly relevant sexually transmitted disease. These three recombinants offer high sensitivity and specificity.

RF1606 represents gene product from Tp0453, in PBS 500 mM NaCl, 3M Urea $600/mg
RF1657 represents p17, in PBS 500 mM NaCl, 3M Urea $600/mg
RF1658 represents p15, in PBS 500 mM NaCl, 3M Urea $600/mg

Autoimmune Antigen

SS-A 60 and 52 are heterogeneous antigens that are important markers in Sjogren’s Syndrome and other connective tissue diseases. JO-1 is a key marker in polymyositis and dermatomyositis as well as other autoimmune diseases. SS-B is also a significant marker in Sjogren’s Syndrome and may be seen in SLE patients. SCL-70 is a crucial marker in scleroderma and crest patients. U1-RNP is an important marker of mixed connective tissue disease.

RF1922 SS-A, 60 kd protein, PBS 500 mM NaCl, 5M Urea $600/mg
RF1924 SS-A, 52 kd protein, PBS 500 mM NaCl, 3M Urea $600/mg
RF1926 J0-1, PBS 500 mM NaCl $600/mg
RF1927 SS-B, PBS 500 mM NaCl $600/mg
RF1928 SCL-70, PBS 500 mM NaCl $600/mg
RF1929 U1-RNP, PBS 500 mM NaCl, 3M Urea $600/mg